Lithium Induced Diabetes Insipidus, Trauma and the Shrunken Brain

Lithium-induced nephrogenic diabetes insipidus.

BACKGROUND Lithium can cause nephrogenic diabetes insipidus in up to 20 to 40 percent of patients currently taking the medication, and a subset of these patients will have a persistent concentrating defect long after lithium is discontinued. They are at risk for serious hypernatremia when fluid intake is restricted for any reason. METHODS MEDLINE as used to search the key words "nephrogenic d...

Diabetes Insipidus and Trauma (15 Cases Report)

SUMMARY In a survey during a period of 3 years (1363 -1366), we have studied 15 Patients with diabetes insipidus due to accidents, measless and surgery. Finally, after this period we find that permanent diabetes insipid us was clear in (2 head. injury, 2 patients with head measle, and two after surgery for craniopharyngioma). In eight rest patients diabetes insipid us was temporary and subside...

Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus.

To reduce lithium-induced nephrogenic diabetes insipidus (lithium-NDI), patients with bipolar disorder are treated with thiazide and amiloride, which are thought to induce antidiuresis by a compensatory increase in prourine uptake in proximal tubules. However, thiazides induced antidiuresis and alkalinized the urine in lithium-NDI mice lacking the sodium-chloride cotransporter, suggesting that ...

Management and treatment of lithium- induced nephrogenic diabetes insipidus

Hyperosmolar nonketotic coma precipitated by lithium-induced nephrogenic diabetes insipidus.

A 45-year-old man, with a 10-year history of manic depression treated with lithium, was admitted with hyperosmolar, nonketotic coma. He gave a five-year history of polyuria and polydipsia, during which time urinalysis had been negative for glucose. After recovery from hyperglycaemia, he remained polyuric despite normal blood glucose concentrations; water deprivation testing indicated nephrogeni...